Polymorphisms of CYP2C8 Alter First-Electron Transfer Kinetics and Increase Catalytic Uncoupling

Polymorphisms of CYP2C8 Alter First-Electron Transfer Kinetics and Increase Catalytic Uncoupling

Cytochrome P450 2C8 (CYP2C8) epoxygenase is responsible for the metabolism of over 60 clinically relevant drugs, notably the anticancer drug Taxol (paclitaxel, PAC). Specifically, there are naturally occurring polymorphisms, CYP2C8*2 and CYP2C8*3, that display altered PAC hydroxylation rates despite...

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Bibliographic Details
Main Authors: William R. Arnold, Susan Zelasko, Daryl D. Meling, Kimberly Sam, Aditi Das
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:International Journal of Molecular Sciences
Subjects:
CYP2C8
polymorphisms
reactive oxygen species
paclitaxel
cytochrome P450 reductase
electron transfer
Online Access:https://www.mdpi.com/1422-0067/20/18/4626

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