The Evaluation of Dose Enhancement within Gold Nanoparticle Radio-Sensitized Tumor Using Proton Therapy

Background: Because of its radio-biological and physical advantages, proton therapy method is highly popular compared to other radiotherapy methods. Recent attempts at enhancing dose in tumors and reducing dose in adjacent tissues have been mainly relying on the use of metal nanoparticles with the a...

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Main Authors: Somayeh Malmir, Ali Asghar Molavi, Saeed Mohammadi
Format: Article
Language:fas
Published: Vesnu Publications 2017-02-01
Series:مجله دانشکده پزشکی اصفهان
Subjects:
Online Access:http://jims.mui.ac.ir/index.php/jims/article/view/7321
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spelling doaj-d03a8f92397c453ab1de4261d40461bd2020-11-25T01:12:53ZfasVesnu Publications مجله دانشکده پزشکی اصفهان1027-75951735-854X2017-02-0134408141414222374The Evaluation of Dose Enhancement within Gold Nanoparticle Radio-Sensitized Tumor Using Proton TherapySomayeh Malmir0Ali Asghar Molavi1Saeed Mohammadi2PhD Student, Department of Physics, Payame Noor University of Tehran, Tehran, IranProfessor, Department of Physics, School of Basic Sciences, Hakim Sabzevari University, Sabzevar, IranProfessor, Department of Physics, School of Basic Sciences, Payame Noor University, Tehran, IranBackground: Because of its radio-biological and physical advantages, proton therapy method is highly popular compared to other radiotherapy methods. Recent attempts at enhancing dose in tumors and reducing dose in adjacent tissues have been mainly relying on the use of metal nanoparticles with the aim of activating tumors. Numerous qualitative studies have been carried out on the safety and clinical use of gold nanoparticles and the results have been promising. However, some quantitative studies should be conducted to examine the factors affecting this method. With respect to the performance of Monte Carlo Method in simulation of the particles transport, the aim of this article was to obtain the dose enhancement in tumor sensitized by gold nanoparticles (GNPs) using MCNPX code. Methods: A slab head phantom with homogenized-GNPs-aided tumor was considered to simulate proton therapy in brain tissue. Monte Carlo simulation was performed using MCNPX code to assess the dose and its enhancement in a radio-sensitized tumor by GNPs using proton therapy. Findings: The Bragg peak calculations were conducted for proton beams with energies in the rage of 40-150 Mev. Dose and its enhancements in tumor were obtained for several concentrations. Then, Spread-out Bragg Peak (SOBP) was evaluated. Conclusion: According to our calculations, if the protons energy is high enough so that they can pass the sensitized tumor; dose will be improved in Bragg peak and then, will decrease immediately. In addition, in relation to the SOBP, solid dose enhancement in sensitized tumor and decreasing the dose immediately after it, were concluded. Dose enhancement due to the presence of nanoparticles in the tumor confirms the results of previous research. But, a significant reduction in the dose immediately after the tumor was the result of this research.http://jims.mui.ac.ir/index.php/jims/article/view/7321Proton therapyGold nanoparticles (GNPs) radio-sensitizationdose enhancementMCNPX Code
collection DOAJ
language fas
format Article
sources DOAJ
author Somayeh Malmir
Ali Asghar Molavi
Saeed Mohammadi
spellingShingle Somayeh Malmir
Ali Asghar Molavi
Saeed Mohammadi
The Evaluation of Dose Enhancement within Gold Nanoparticle Radio-Sensitized Tumor Using Proton Therapy
مجله دانشکده پزشکی اصفهان
Proton therapy
Gold nanoparticles (GNPs) radio-sensitization
dose enhancement
MCNPX Code
author_facet Somayeh Malmir
Ali Asghar Molavi
Saeed Mohammadi
author_sort Somayeh Malmir
title The Evaluation of Dose Enhancement within Gold Nanoparticle Radio-Sensitized Tumor Using Proton Therapy
title_short The Evaluation of Dose Enhancement within Gold Nanoparticle Radio-Sensitized Tumor Using Proton Therapy
title_full The Evaluation of Dose Enhancement within Gold Nanoparticle Radio-Sensitized Tumor Using Proton Therapy
title_fullStr The Evaluation of Dose Enhancement within Gold Nanoparticle Radio-Sensitized Tumor Using Proton Therapy
title_full_unstemmed The Evaluation of Dose Enhancement within Gold Nanoparticle Radio-Sensitized Tumor Using Proton Therapy
title_sort evaluation of dose enhancement within gold nanoparticle radio-sensitized tumor using proton therapy
publisher Vesnu Publications
series مجله دانشکده پزشکی اصفهان
issn 1027-7595
1735-854X
publishDate 2017-02-01
description Background: Because of its radio-biological and physical advantages, proton therapy method is highly popular compared to other radiotherapy methods. Recent attempts at enhancing dose in tumors and reducing dose in adjacent tissues have been mainly relying on the use of metal nanoparticles with the aim of activating tumors. Numerous qualitative studies have been carried out on the safety and clinical use of gold nanoparticles and the results have been promising. However, some quantitative studies should be conducted to examine the factors affecting this method. With respect to the performance of Monte Carlo Method in simulation of the particles transport, the aim of this article was to obtain the dose enhancement in tumor sensitized by gold nanoparticles (GNPs) using MCNPX code. Methods: A slab head phantom with homogenized-GNPs-aided tumor was considered to simulate proton therapy in brain tissue. Monte Carlo simulation was performed using MCNPX code to assess the dose and its enhancement in a radio-sensitized tumor by GNPs using proton therapy. Findings: The Bragg peak calculations were conducted for proton beams with energies in the rage of 40-150 Mev. Dose and its enhancements in tumor were obtained for several concentrations. Then, Spread-out Bragg Peak (SOBP) was evaluated. Conclusion: According to our calculations, if the protons energy is high enough so that they can pass the sensitized tumor; dose will be improved in Bragg peak and then, will decrease immediately. In addition, in relation to the SOBP, solid dose enhancement in sensitized tumor and decreasing the dose immediately after it, were concluded. Dose enhancement due to the presence of nanoparticles in the tumor confirms the results of previous research. But, a significant reduction in the dose immediately after the tumor was the result of this research.
topic Proton therapy
Gold nanoparticles (GNPs) radio-sensitization
dose enhancement
MCNPX Code
url http://jims.mui.ac.ir/index.php/jims/article/view/7321
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