Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

Heart grafts need good vascularization to survive. Here, the authors engineer perfusable constructs of human embryonic stem cell-derived endothelial cells seeded in collagen matrix in patterned microchannels that form anastomosed vessels in vitro and have increased coronary vascular perfusion on tra...

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Main Authors:	Meredith A. Redd, Nicole Zeinstra, Wan Qin, Wei Wei, Amy Martinson, Yuliang Wang, Ruikang K. Wang, Charles E. Murry, Ying Zheng
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-02-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-08388-7

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spelling	doaj-d0353d4f8b0744d1a71917d43e8a02a62021-05-11T11:45:24ZengNature Publishing GroupNature Communications2041-17232019-02-0110111410.1038/s41467-019-08388-7Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat heartsMeredith A. Redd0Nicole Zeinstra1Wan Qin2Wei Wei3Amy Martinson4Yuliang Wang5Ruikang K. Wang6Charles E. Murry7Ying Zheng8Department of Bioengineering, University of WashingtonDepartment of Bioengineering, University of WashingtonDepartment of Bioengineering, University of WashingtonDepartment of Bioengineering, University of WashingtonCenter for Cardiovascular Biology, University of WashingtonInstitute for Stem Cell and Regenerative Medicine, University of WashingtonDepartment of Bioengineering, University of WashingtonDepartment of Bioengineering, University of WashingtonDepartment of Bioengineering, University of WashingtonHeart grafts need good vascularization to survive. Here, the authors engineer perfusable constructs of human embryonic stem cell-derived endothelial cells seeded in collagen matrix in patterned microchannels that form anastomosed vessels in vitro and have increased coronary vascular perfusion on transplantation in rats.https://doi.org/10.1038/s41467-019-08388-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Meredith A. Redd Nicole Zeinstra Wan Qin Wei Wei Amy Martinson Yuliang Wang Ruikang K. Wang Charles E. Murry Ying Zheng
spellingShingle	Meredith A. Redd Nicole Zeinstra Wan Qin Wei Wei Amy Martinson Yuliang Wang Ruikang K. Wang Charles E. Murry Ying Zheng Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts Nature Communications
author_facet	Meredith A. Redd Nicole Zeinstra Wan Qin Wei Wei Amy Martinson Yuliang Wang Ruikang K. Wang Charles E. Murry Ying Zheng
author_sort	Meredith A. Redd
title	Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
title_short	Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
title_full	Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
title_fullStr	Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
title_full_unstemmed	Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
title_sort	patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-02-01
description	Heart grafts need good vascularization to survive. Here, the authors engineer perfusable constructs of human embryonic stem cell-derived endothelial cells seeded in collagen matrix in patterned microchannels that form anastomosed vessels in vitro and have increased coronary vascular perfusion on transplantation in rats.
url	https://doi.org/10.1038/s41467-019-08388-7
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Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts

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