Association and Predictive Value Analysis for Resting Heart Rate and Diabetes Mellitus on Cardiovascular Autonomic Neuropathy in General Population

Background. The purpose of this study was to evaluate the predictive value of DM and resting HR on CAN in a large sample derived from a Chinese population. Materials and Methods. We conducted a large-scale, population-based, cross-sectional study to explore the relationships of CAN with DM and rest...

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Main Authors: Zi-Hui Tang, Fangfang Zeng, Zhongtao Li, Linuo Zhou
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Journal of Diabetes Research
Online Access:http://dx.doi.org/10.1155/2014/215473
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spelling doaj-d0327702968240d5907753f426a124ab2020-11-24T23:13:07ZengHindawi LimitedJournal of Diabetes Research2314-67452314-67532014-01-01201410.1155/2014/215473215473Association and Predictive Value Analysis for Resting Heart Rate and Diabetes Mellitus on Cardiovascular Autonomic Neuropathy in General PopulationZi-Hui Tang0Fangfang Zeng1Zhongtao Li2Linuo Zhou3Department of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No. 12 Wulumuqi Mid Road, Building No. 0, Jing’an District, Shanghai 200040, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No. 12 Wulumuqi Mid Road, Building No. 0, Jing’an District, Shanghai 200040, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No. 12 Wulumuqi Mid Road, Building No. 0, Jing’an District, Shanghai 200040, ChinaDepartment of Endocrinology and Metabolism, Huashan Hospital, Fudan University, No. 12 Wulumuqi Mid Road, Building No. 0, Jing’an District, Shanghai 200040, ChinaBackground. The purpose of this study was to evaluate the predictive value of DM and resting HR on CAN in a large sample derived from a Chinese population. Materials and Methods. We conducted a large-scale, population-based, cross-sectional study to explore the relationships of CAN with DM and resting HR. A total of 387 subjects were diagnosed with CAN in our dataset. The associations of CAN with DM and resting HR were assessed by a multivariate logistic regression (MLR) analysis (using subjects without CAN as a reference group) after controlling for potential confounding factors. The area under the receiver-operating characteristic curve (AUC) was used to evaluate the predictive performance of resting HR and DM. Results. A tendency toward increased CAN prevalence with increasing resting HR was reported (P for trend <0.001). MLR analysis showed that DM and resting HR were very significantly and independently associated with CAN (P<0.001 for both). Resting HR alone or combined with DM (DM-HR) both strongly predicted CAN (AUC = 0.719, 95% CI 0.690–0.748 for resting HR and AUC = 0.738, 95% CI 0.710–0.766 for DM-HR). Conclusion. Our findings signify that resting HR and DM-HR have a high value in predicting CAN in the general population.http://dx.doi.org/10.1155/2014/215473
collection DOAJ
language English
format Article
sources DOAJ
author Zi-Hui Tang
Fangfang Zeng
Zhongtao Li
Linuo Zhou
spellingShingle Zi-Hui Tang
Fangfang Zeng
Zhongtao Li
Linuo Zhou
Association and Predictive Value Analysis for Resting Heart Rate and Diabetes Mellitus on Cardiovascular Autonomic Neuropathy in General Population
Journal of Diabetes Research
author_facet Zi-Hui Tang
Fangfang Zeng
Zhongtao Li
Linuo Zhou
author_sort Zi-Hui Tang
title Association and Predictive Value Analysis for Resting Heart Rate and Diabetes Mellitus on Cardiovascular Autonomic Neuropathy in General Population
title_short Association and Predictive Value Analysis for Resting Heart Rate and Diabetes Mellitus on Cardiovascular Autonomic Neuropathy in General Population
title_full Association and Predictive Value Analysis for Resting Heart Rate and Diabetes Mellitus on Cardiovascular Autonomic Neuropathy in General Population
title_fullStr Association and Predictive Value Analysis for Resting Heart Rate and Diabetes Mellitus on Cardiovascular Autonomic Neuropathy in General Population
title_full_unstemmed Association and Predictive Value Analysis for Resting Heart Rate and Diabetes Mellitus on Cardiovascular Autonomic Neuropathy in General Population
title_sort association and predictive value analysis for resting heart rate and diabetes mellitus on cardiovascular autonomic neuropathy in general population
publisher Hindawi Limited
series Journal of Diabetes Research
issn 2314-6745
2314-6753
publishDate 2014-01-01
description Background. The purpose of this study was to evaluate the predictive value of DM and resting HR on CAN in a large sample derived from a Chinese population. Materials and Methods. We conducted a large-scale, population-based, cross-sectional study to explore the relationships of CAN with DM and resting HR. A total of 387 subjects were diagnosed with CAN in our dataset. The associations of CAN with DM and resting HR were assessed by a multivariate logistic regression (MLR) analysis (using subjects without CAN as a reference group) after controlling for potential confounding factors. The area under the receiver-operating characteristic curve (AUC) was used to evaluate the predictive performance of resting HR and DM. Results. A tendency toward increased CAN prevalence with increasing resting HR was reported (P for trend <0.001). MLR analysis showed that DM and resting HR were very significantly and independently associated with CAN (P<0.001 for both). Resting HR alone or combined with DM (DM-HR) both strongly predicted CAN (AUC = 0.719, 95% CI 0.690–0.748 for resting HR and AUC = 0.738, 95% CI 0.710–0.766 for DM-HR). Conclusion. Our findings signify that resting HR and DM-HR have a high value in predicting CAN in the general population.
url http://dx.doi.org/10.1155/2014/215473
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