DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo.

DNMT3L modulates significant and distinct flanking sequence preference for DNA methylation by DNMT3A and DNMT3B in vivo.

The DNTM3A and DNMT3B de novo DNA methyltransferases (DNMTs) are responsible for setting genomic DNA methylation patterns, a key layer of epigenetic information. Here, using an in vivo episomal methylation assay and extensive bisulfite methylation sequencing, we show that human DNMT3A and DNMT3B pos...

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Bibliographic Details
Main Authors: Bethany L Wienholz, Michael S Kareta, Amir H Moarefi, Catherine A Gordon, Paul A Ginno, Frédéric Chédin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2936528?pdf=render

Internet

http://europepmc.org/articles/PMC2936528?pdf=render

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