MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm

MKL1 cooperates with p38MAPK to promote vascular senescence, inflammation, and abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) is a catastrophic disease with little effective therapy. Myocardin related transcription factor A (MRTFA, MKL1) is a multifaceted transcription factor, regulating diverse biological processes. However, a detailed understanding of the mechanistic role of MKL1 in AAA ha...

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Bibliographic Details
Main Authors: Ping Gao, Pan Gao, Jinjing Zhao, Shengshuai Shan, Wei Luo, Orazio J. Slivano, Wei Zhang, Akiko Tabuchi, Scott A. LeMaire, Lars Maegdefessel, Ying H. Shen, Joseph M. Miano, Harold A. Singer, Xiaochun Long
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Redox Biology
Subjects:
Aortic aneurysm
MKL1
p38MAPK
Senescence
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721000513

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