Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy

It is difficult to improve the efficacy of oncolytic virotherapy due to immune system responses and limited understanding of population dynamics. Here the authors use synthetic biology gene circuits to control adenoviral replication and release of immunomodulators in hepatocellular carcinoma cells.

Bibliographic Details
Main Authors: Huiya Huang, Yiqi Liu, Weixi Liao, Yubing Cao, Qiang Liu, Yakun Guo, Yinying Lu, Zhen Xie
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12794-2
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spelling doaj-d02993ca48bb47c3813974088403a7cc2021-05-11T11:39:20ZengNature Publishing GroupNature Communications2041-17232019-10-0110111510.1038/s41467-019-12794-2Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapyHuiya Huang0Yiqi Liu1Weixi Liao2Yubing Cao3Qiang Liu4Yakun Guo5Yinying Lu6Zhen Xie7MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, Department of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua UniversitySyngentech Inc., Zhongguancun Life Science ParkMOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, Department of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua UniversitySyngentech Inc., Zhongguancun Life Science ParkSyngentech Inc., Zhongguancun Life Science ParkSyngentech Inc., Zhongguancun Life Science ParkThe comprehensive Liver cancer center, The 5th medical center of PLA Genaral HospitalMOE Key Laboratory of Bioinformatics and Bioinformatics Division, Center for Synthetic and System Biology, Department of Automation, Beijing National Research Center for Information Science and Technology, Tsinghua UniversityIt is difficult to improve the efficacy of oncolytic virotherapy due to immune system responses and limited understanding of population dynamics. Here the authors use synthetic biology gene circuits to control adenoviral replication and release of immunomodulators in hepatocellular carcinoma cells.https://doi.org/10.1038/s41467-019-12794-2
collection DOAJ
language English
format Article
sources DOAJ
author Huiya Huang
Yiqi Liu
Weixi Liao
Yubing Cao
Qiang Liu
Yakun Guo
Yinying Lu
Zhen Xie
spellingShingle Huiya Huang
Yiqi Liu
Weixi Liao
Yubing Cao
Qiang Liu
Yakun Guo
Yinying Lu
Zhen Xie
Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
Nature Communications
author_facet Huiya Huang
Yiqi Liu
Weixi Liao
Yubing Cao
Qiang Liu
Yakun Guo
Yinying Lu
Zhen Xie
author_sort Huiya Huang
title Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
title_short Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
title_full Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
title_fullStr Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
title_full_unstemmed Oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
title_sort oncolytic adenovirus programmed by synthetic gene circuit for cancer immunotherapy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description It is difficult to improve the efficacy of oncolytic virotherapy due to immune system responses and limited understanding of population dynamics. Here the authors use synthetic biology gene circuits to control adenoviral replication and release of immunomodulators in hepatocellular carcinoma cells.
url https://doi.org/10.1038/s41467-019-12794-2
work_keys_str_mv AT huiyahuang oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy
AT yiqiliu oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy
AT weixiliao oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy
AT yubingcao oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy
AT qiangliu oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy
AT yakunguo oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy
AT yinyinglu oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy
AT zhenxie oncolyticadenovirusprogrammedbysyntheticgenecircuitforcancerimmunotherapy
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