Toll-like receptor 9 polymorphisms influence mother-to-child transmission of human immunodeficiency virus type 1

• Main Authors: Giaquinto Carlo, Montagna Marco, Mosconi Ilaria, Zanchetta Marisa, Malacrida Sandro, Ricci Elisabetta, De Rossi Anita
• Format: Article
• Language: English
• Published: BMC 2010-05-01
• Series: Journal of Translational Medicine
• Online Access: http://www.translational-medicine.com/content/8/1/49

<p>Abstract</p> <p>Background</p> <p>Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns and play a crucial role in the host's innate immune response. Genetic variations in TLR genes may influence host-viral interactions and might impact upon the risk of mother-to-child transmission (MTCT) of Human Immunodeficiency Virus type 1 (HIV-1). The aim of this study was to investigate the influence of genetic variants of TLR 9 gene on MTCT.</p> <p>Methods</p> <p>Three hundred children (118 HIV-1-infected and 182 HIV-1-uninfected) born to HIV-1-infected mothers were studied. Single nucleotide polymorphisms (SNPs) <ext-link ext-link-id="NM_017442.2" ext-link-type="gen">NM_017442.2</ext-link>: c.4-44G > A (rs352139) and c.1635A > G (rs352140) of the TLR9 gene were genotyped by TaqMan allelic discrimination assay. Statistical analyses were performed using SNPStats program.</p> <p>Results</p> <p>When considered separately, neither of the two SNPs was significantly associated with risk of HIV-1 infection. However, the [A;A] and [G;G] haplotypes were associated with a higher risk of HIV-1 infection compared to the prevalent [G;A] haplotype [odds ratio (OR) = 3.16, 95% confidence interval (CI) 1.24-8.03, p = 0.016, and OR = 5.54, 95% CI 1.76-17.50, p = 0.004, respectively].</p> <p>Conclusions</p> <p>Overall, results demonstrate a significant correlation between specific genetic variants of the TLR9 gene and risk of MTCT of HIV-1, thus confirming a critical role of innate immunity in perinatal HIV-1 infection. Strategies aimed at modulating innate immunity might be useful for future treatment of pediatric HIV-1 infection and AIDS.</p>