Inflammation Based Regulation of Cancer Cachexia

Inflammation Based Regulation of Cancer Cachexia

Cancer cachexia, consisting of significant skeletal muscle wasting independent of nutritional intake, is a major concern for patients with solid tumors that affects surgical, therapeutic, and quality of life outcomes. This review summarizes the clinical implications, background of inflammatory cytok...

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Main Authors: Jill K. Onesti, Denis C. Guttridge
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:BioMed Research International
Online Access:http://dx.doi.org/10.1155/2014/168407
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spelling doaj-d00a029c25d542af90e7f95d3365bae92020-11-25T02:57:23ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/168407168407Inflammation Based Regulation of Cancer CachexiaJill K. Onesti0Denis C. Guttridge1Division of Surgical Oncology, The Ohio State University Wexner Medical Center, The Ohio State University College of Medicine, 460 W. 12th Avenue, Columbus, OH 43210, USAThe Arthur G. James Comprehensive Cancer Center, Columbus, OH 43210, USACancer cachexia, consisting of significant skeletal muscle wasting independent of nutritional intake, is a major concern for patients with solid tumors that affects surgical, therapeutic, and quality of life outcomes. This review summarizes the clinical implications, background of inflammatory cytokines, and the origin and sources of procachectic factors including TNF-α, IL-6, IL-1, INF-γ, and PIF. Molecular mechanisms and pathways are described to elucidate the link between the immune response caused by the presence of the tumor and the final result of skeletal muscle wasting.http://dx.doi.org/10.1155/2014/168407
collection DOAJ
language English
format Article
sources DOAJ
author Jill K. Onesti
Denis C. Guttridge
spellingShingle Jill K. Onesti
Denis C. Guttridge
Inflammation Based Regulation of Cancer Cachexia
BioMed Research International
author_facet Jill K. Onesti
Denis C. Guttridge
author_sort Jill K. Onesti
title Inflammation Based Regulation of Cancer Cachexia
title_short Inflammation Based Regulation of Cancer Cachexia
title_full Inflammation Based Regulation of Cancer Cachexia
title_fullStr Inflammation Based Regulation of Cancer Cachexia
title_full_unstemmed Inflammation Based Regulation of Cancer Cachexia
title_sort inflammation based regulation of cancer cachexia
publisher Hindawi Limited
series BioMed Research International
issn 2314-6133
2314-6141
publishDate 2014-01-01
description Cancer cachexia, consisting of significant skeletal muscle wasting independent of nutritional intake, is a major concern for patients with solid tumors that affects surgical, therapeutic, and quality of life outcomes. This review summarizes the clinical implications, background of inflammatory cytokines, and the origin and sources of procachectic factors including TNF-α, IL-6, IL-1, INF-γ, and PIF. Molecular mechanisms and pathways are described to elucidate the link between the immune response caused by the presence of the tumor and the final result of skeletal muscle wasting.
url http://dx.doi.org/10.1155/2014/168407
work_keys_str_mv AT jillkonesti inflammationbasedregulationofcancercachexia
AT deniscguttridge inflammationbasedregulationofcancercachexia
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