Synthesis of the Marine Bromotyrosine Psammaplin F and Crystal Structure of a Psammaplin A Analogue

Synthesis of the Marine Bromotyrosine Psammaplin F and Crystal Structure of a Psammaplin A Analogue

Psammaplin F, an unsymmetrical disulfide bromotyrosine, was isolated from the sponge Pseudoceratina purpurea in 2003. We reported here the first total synthesis of psammaplin F in 12% overall yield by employing Cleland’s reagent reduction as key step. The longest linear synthetic sequence starting f...

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Bibliographic Details
Main Authors: Linxiang Zhao, Zuti Wu, Guodong Hu, Sen Yang, Deyang Sun, Dan Liu, Qianjiao Yang
Format: Article
Language:English
Published: MDPI AG 2010-12-01
Series:Molecules
Subjects:
psammaplin F
marine bromotyrosine
Cleland’s reagent
total synthesis
X-ray crystal structure
Online Access:http://www.mdpi.com/1420-3049/15/12/8784/

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