Identification of Toxic Pyrrolizidine Alkaloids and Their Common Hepatotoxicity Mechanism

Identification of Toxic Pyrrolizidine Alkaloids and Their Common Hepatotoxicity Mechanism

Pyrrolizidine Alkaloids (PAs) are currently one of the most important botanical hepatotoxic ingredients. Glutathion (GSH) metabolism is the most reported pathway involved in hepatotoxicity mechanism of PAs. We speculate that, for different PAs, there should be a common mechanism underlying their hep...

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Bibliographic Details
Main Authors: Xinmiao Yan, Hong Kang, Jun Feng, Yiyan Yang, Kailin Tang, Ruixin Zhu, Li Yang, Zhengtao Wang, Zhiwei Cao
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:International Journal of Molecular Sciences
Subjects:
Pyrrolizidine Alkaloids
hepatotoxicity mechanism
glutathion metabolism
reverse docking
Online Access:http://www.mdpi.com/1422-0067/17/3/318

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