The Role of Protein Kinase B Signaling Pathway in Anti-cancer Effect of Rolipram on Glioblastoma Multiforme: An In Vitro Study

The Role of Protein Kinase B Signaling Pathway in Anti-cancer Effect of Rolipram on Glioblastoma Multiforme: An In Vitro Study

Introduction: The mechanism of putative cytotoxicity of 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidone (rolipram), a specific phosphodiesterase-4 (PDE4) inhibitor, on glioblastoma multiforme (GBM) is almost unknown. This study aimed to investigate the role of protein kinase B (Akt) pathway in...

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Bibliographic Details
Main Authors: Sara Ramezani, Mahmoudreza Hadjighassem, Nasim Vousooghi, Mansour Parvaresh, Farshid Arbabi, Naser Amini, Mohammad Taghi Joghataei
Format: Article
Language:English
Published: Iran University of Medical Sciences 2017-07-01
Series:Basic and Clinical Neuroscience
Subjects:
Glioblastoma multiforme
Rolipram
SC79
U87 MG cell line
Tumor-initiating cells
Akt signal
Online Access:http://bcn.iums.ac.ir/browse.php?a_code=A-10-983-1&slc_lang=en&sid=1

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