Role of tumor necrosis factor-alpha-induced protein 8-like 2 in development and progression of liver and gastrointestinal tumors
Liver and gastrointestinal tumors greatly threaten human health and have poor therapeutic outcomes and prognosis. Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) can negatively regulate innate immunity and adaptive immunity and maintain immune homeostasis. Recent studies have found that...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Hepatology
2017-01-01
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| Series: | Linchuang Gandanbing Zazhi |
| Online Access: | http://www.lcgdbzz.org/qk_content.asp?id=7965 |
| Summary: | Liver and gastrointestinal tumors greatly threaten human health and have poor therapeutic outcomes and prognosis. Tumor necrosis factor-alpha-induced protein 8-like 2 (TIPE2) can negatively regulate innate immunity and adaptive immunity and maintain immune homeostasis. Recent studies have found that TIPE2 can affect various signaling pathways and thus exerts an inhibitory effect on the development and progression of tumors. This article briefly introduces the structure and function of TIPE2 and its regulatory effect on tumor-related signaling pathways such as Ras, Ral, and Rac and downstream molecules, as well as the role of TIPE2 in liver and gastrointestinal tumors, related signaling pathways, and research advances. |
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| ISSN: | 1001-5256 1001-5256 |