Pathways for Oral and Rectal Delivery of Gold Nanoparticles (1.7 nm) and Gold Nanoclusters into the Colon: Enteric-Coated Capsules and Suppositories

Two ways to deliver ultrasmall gold nanoparticles and gold-bovine serum albumin (BSA) nanoclusters to the colon were developed. First, oral administration is possible by incorporation into gelatin capsules that were coated with an enteric polymer. These permit the transfer across the stomach whose a...

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Main Authors:	Shabnam Hosseini, Oliver Wetzel, Kathrin Kostka, Marc Heggen, Kateryna Loza, Matthias Epple
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	Molecules
Subjects:	capsules colon drug delivery gold nanoparticles suppositories
Online Access:	https://www.mdpi.com/1420-3049/26/16/5069

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spelling	doaj-cfe4bf5001ae469e9d741d54057d1f852021-08-26T14:08:17ZengMDPI AGMolecules1420-30492021-08-01265069506910.3390/molecules26165069Pathways for Oral and Rectal Delivery of Gold Nanoparticles (1.7 nm) and Gold Nanoclusters into the Colon: Enteric-Coated Capsules and SuppositoriesShabnam Hosseini0Oliver Wetzel1Kathrin Kostka2Marc Heggen3Kateryna Loza4Matthias Epple5Inorganic Chemistry and Centre for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117 Essen, GermanyInorganic Chemistry and Centre for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117 Essen, GermanyInorganic Chemistry and Centre for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117 Essen, GermanyErnst Ruska Centre for Microscopy and Spectroscopy with Electrons, Forschungszentrum Jülich GmbH, 52428 Jülich, GermanyInorganic Chemistry and Centre for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117 Essen, GermanyInorganic Chemistry and Centre for Nanointegration Duisburg-Essen (CeNIDE), University of Duisburg-Essen, Universitaetsstr. 5-7, 45117 Essen, GermanyTwo ways to deliver ultrasmall gold nanoparticles and gold-bovine serum albumin (BSA) nanoclusters to the colon were developed. First, oral administration is possible by incorporation into gelatin capsules that were coated with an enteric polymer. These permit the transfer across the stomach whose acidic environment damages many drugs. The enteric coating dissolves due to the neutral pH of the colon and releases the capsule’s cargo. Second, rectal administration is possible by incorporation into hard-fat suppositories that melt in the colon and then release the nanocarriers. The feasibility of the two concepts was demonstrated by in-vitro release studies and cell culture studies that showed the easy redispersibility after dissolution of the respective transport system. This clears a pathway for therapeutic applications of drug-loaded nanoparticles to address colon diseases, such as chronic inflammation and cancer.https://www.mdpi.com/1420-3049/26/16/5069capsulescolondrug deliverygoldnanoparticlessuppositories
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Shabnam Hosseini Oliver Wetzel Kathrin Kostka Marc Heggen Kateryna Loza Matthias Epple
spellingShingle	Shabnam Hosseini Oliver Wetzel Kathrin Kostka Marc Heggen Kateryna Loza Matthias Epple Pathways for Oral and Rectal Delivery of Gold Nanoparticles (1.7 nm) and Gold Nanoclusters into the Colon: Enteric-Coated Capsules and Suppositories Molecules capsules colon drug delivery gold nanoparticles suppositories
author_facet	Shabnam Hosseini Oliver Wetzel Kathrin Kostka Marc Heggen Kateryna Loza Matthias Epple
author_sort	Shabnam Hosseini
title	Pathways for Oral and Rectal Delivery of Gold Nanoparticles (1.7 nm) and Gold Nanoclusters into the Colon: Enteric-Coated Capsules and Suppositories
title_short	Pathways for Oral and Rectal Delivery of Gold Nanoparticles (1.7 nm) and Gold Nanoclusters into the Colon: Enteric-Coated Capsules and Suppositories
title_full	Pathways for Oral and Rectal Delivery of Gold Nanoparticles (1.7 nm) and Gold Nanoclusters into the Colon: Enteric-Coated Capsules and Suppositories
title_fullStr	Pathways for Oral and Rectal Delivery of Gold Nanoparticles (1.7 nm) and Gold Nanoclusters into the Colon: Enteric-Coated Capsules and Suppositories
title_full_unstemmed	Pathways for Oral and Rectal Delivery of Gold Nanoparticles (1.7 nm) and Gold Nanoclusters into the Colon: Enteric-Coated Capsules and Suppositories
title_sort	pathways for oral and rectal delivery of gold nanoparticles (1.7 nm) and gold nanoclusters into the colon: enteric-coated capsules and suppositories
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2021-08-01
description	Two ways to deliver ultrasmall gold nanoparticles and gold-bovine serum albumin (BSA) nanoclusters to the colon were developed. First, oral administration is possible by incorporation into gelatin capsules that were coated with an enteric polymer. These permit the transfer across the stomach whose acidic environment damages many drugs. The enteric coating dissolves due to the neutral pH of the colon and releases the capsule’s cargo. Second, rectal administration is possible by incorporation into hard-fat suppositories that melt in the colon and then release the nanocarriers. The feasibility of the two concepts was demonstrated by in-vitro release studies and cell culture studies that showed the easy redispersibility after dissolution of the respective transport system. This clears a pathway for therapeutic applications of drug-loaded nanoparticles to address colon diseases, such as chronic inflammation and cancer.
topic	capsules colon drug delivery gold nanoparticles suppositories
url	https://www.mdpi.com/1420-3049/26/16/5069
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Pathways for Oral and Rectal Delivery of Gold Nanoparticles (1.7 nm) and Gold Nanoclusters into the Colon: Enteric-Coated Capsules and Suppositories

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