Acetylation regulates WRN catalytic activities and affects base excision DNA repair.

Acetylation regulates WRN catalytic activities and affects base excision DNA repair.

The Werner protein (WRN), defective in the premature aging disorder Werner syndrome, participates in a number of DNA metabolic processes, and we have been interested in the possible regulation of its function in DNA repair by post-translational modifications. Acetylation mediated by histone acetyltr...

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Bibliographic Details
Main Authors: Meltem Muftuoglu, Rika Kusumoto, Elzbieta Speina, Gad Beck, Wen-Hsing Cheng, Vilhelm A Bohr
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2276247?pdf=render

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