A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma

A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma

Management of pyoderma gangrenosum in established malignancy is challenging. When vital structures are at risk from ulceration, aggressive management is required; however, immunosuppressive therapy may compromise the prognosis for an underlying malignancy. The optimal management of pyoderma gangreno...

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Main Authors: Lisa Roche, MBBCh, BAO, Christian Gulman, MBBCh, FRCPath, MD, FFPath (RCPI), Marina O'Kane, MBBCh, BAO
Format: Article
Language:English
Published: Elsevier 2018-06-01
Series:JAAD Case Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2352512618300109
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spelling doaj-cfdc7c51be5d4a658ae8cb455c42bf092020-11-24T23:24:29ZengElsevierJAAD Case Reports2352-51262018-06-0145474476A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphomaLisa Roche, MBBCh, BAO0Christian Gulman, MBBCh, FRCPath, MD, FFPath (RCPI)1Marina O'Kane, MBBCh, BAO2Department of Dermatology, Connolly and Beaumont Hospitals, Dublin, Ireland; Correspondence to: Lisa Roche, MBBCh, BAO, Dermatology Department, 5th Floor Leben Building, University Hospital Limerick, Dooradoyle, Limerick, Ireland V94F858.Department of Histopathology, Beaumont Hospital, Dublin, IrelandDepartment of Dermatology, Connolly and Beaumont Hospitals, Dublin, IrelandManagement of pyoderma gangrenosum in established malignancy is challenging. When vital structures are at risk from ulceration, aggressive management is required; however, immunosuppressive therapy may compromise the prognosis for an underlying malignancy. The optimal management of pyoderma gangrenosum in this setting is unclear. We report on a 64-year-old woman with follicular lymphoma in partial remission, who had severe genital pyoderma gangrenosum. After multidisciplinary evaluation, she was treated with corticosteroids and cyclosporine and healed fully with scarring over 7 weeks. She has required low-dose cyclosporine for 3 years to maintain remission of her genital ulceration; however, she remains well with no relapse of her lymphoma on serial imaging.http://www.sciencedirect.com/science/article/pii/S2352512618300109
collection DOAJ
language English
format Article
sources DOAJ
author Lisa Roche, MBBCh, BAO
Christian Gulman, MBBCh, FRCPath, MD, FFPath (RCPI)
Marina O'Kane, MBBCh, BAO
spellingShingle Lisa Roche, MBBCh, BAO
Christian Gulman, MBBCh, FRCPath, MD, FFPath (RCPI)
Marina O'Kane, MBBCh, BAO
A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma
JAAD Case Reports
author_facet Lisa Roche, MBBCh, BAO
Christian Gulman, MBBCh, FRCPath, MD, FFPath (RCPI)
Marina O'Kane, MBBCh, BAO
author_sort Lisa Roche, MBBCh, BAO
title A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma
title_short A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma
title_full A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma
title_fullStr A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma
title_full_unstemmed A case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma
title_sort case of genital pyoderma gangrenosum successfully treated with cyclosporine without relapse of established follicular lymphoma
publisher Elsevier
series JAAD Case Reports
issn 2352-5126
publishDate 2018-06-01
description Management of pyoderma gangrenosum in established malignancy is challenging. When vital structures are at risk from ulceration, aggressive management is required; however, immunosuppressive therapy may compromise the prognosis for an underlying malignancy. The optimal management of pyoderma gangrenosum in this setting is unclear. We report on a 64-year-old woman with follicular lymphoma in partial remission, who had severe genital pyoderma gangrenosum. After multidisciplinary evaluation, she was treated with corticosteroids and cyclosporine and healed fully with scarring over 7 weeks. She has required low-dose cyclosporine for 3 years to maintain remission of her genital ulceration; however, she remains well with no relapse of her lymphoma on serial imaging.
url http://www.sciencedirect.com/science/article/pii/S2352512618300109
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