Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model

Emerging evidence suggests that gestational or developmental vitamin D (DVD) deficiency is associated with an increased risk of autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder characterized by impairments in social interaction, lack of verbal and non-verbal communications, stere...

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Main Authors:	Asad Ali, Svetlina Vasileva, Mia Langguth, Suzanne Alexander, Xiaoying Cui, Andrew Whitehouse, John J. McGrath, Darryl Eyles
Format:	Article
Language:	English
Published:	MDPI AG 2019-05-01
Series:	Nutrients
Subjects:	Vitamin D autism spectrum disorder behavior brain development animal model ultrasonic vocalizations
Online Access:	https://www.mdpi.com/2072-6643/11/5/1187

id	doaj-cfc1befd4010462e9b8351358e04735f
record_format	Article
spelling	doaj-cfc1befd4010462e9b8351358e04735f2020-11-25T01:51:45ZengMDPI AGNutrients2072-66432019-05-01115118710.3390/nu11051187nu11051187Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal ModelAsad Ali0Svetlina Vasileva1Mia Langguth2Suzanne Alexander3Xiaoying Cui4Andrew Whitehouse5John J. McGrath6Darryl Eyles7Queensland Brain Institute, The University of Queensland, Brisbane, QLD 4076, AustraliaQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4076, AustraliaBrain and Mind Centre, University of Sydney, Sydney, NSW 2050, AustraliaQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4076, AustraliaQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4076, AustraliaTelethon Kids Institute, The University of Western Australia, Perth, WA 6009, AustraliaQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4076, AustraliaQueensland Brain Institute, The University of Queensland, Brisbane, QLD 4076, AustraliaEmerging evidence suggests that gestational or developmental vitamin D (DVD) deficiency is associated with an increased risk of autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder characterized by impairments in social interaction, lack of verbal and non-verbal communications, stereotyped repetitive behaviors and hyper-activities. There are several other clinical features that are commonly comorbid with ASD, including olfactory impairments, anxiety and delays in motor development. Here we investigate these features in an animal model related to ASD—the DVD-deficient rat. Compared to controls, both DVD-deficient male and female pups show altered ultrasonic vocalizations and stereotyped repetitive behavior. Further, the DVD-deficient animals had delayed motor development and impaired motor control. Adolescent DVD-deficient animals had impaired reciprocal social interaction, while as adults, these animals were hyperactive. The DVD-deficient model is associated with a range of behavioral features of interest to ASD.https://www.mdpi.com/2072-6643/11/5/1187Vitamin Dautism spectrum disorderbehaviorbrain developmentanimal modelultrasonic vocalizations
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Asad Ali Svetlina Vasileva Mia Langguth Suzanne Alexander Xiaoying Cui Andrew Whitehouse John J. McGrath Darryl Eyles
spellingShingle	Asad Ali Svetlina Vasileva Mia Langguth Suzanne Alexander Xiaoying Cui Andrew Whitehouse John J. McGrath Darryl Eyles Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model Nutrients Vitamin D autism spectrum disorder behavior brain development animal model ultrasonic vocalizations
author_facet	Asad Ali Svetlina Vasileva Mia Langguth Suzanne Alexander Xiaoying Cui Andrew Whitehouse John J. McGrath Darryl Eyles
author_sort	Asad Ali
title	Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model
title_short	Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model
title_full	Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model
title_fullStr	Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model
title_full_unstemmed	Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model
title_sort	developmental vitamin d deficiency produces behavioral phenotypes of relevance to autism in an animal model
publisher	MDPI AG
series	Nutrients
issn	2072-6643
publishDate	2019-05-01
description	Emerging evidence suggests that gestational or developmental vitamin D (DVD) deficiency is associated with an increased risk of autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder characterized by impairments in social interaction, lack of verbal and non-verbal communications, stereotyped repetitive behaviors and hyper-activities. There are several other clinical features that are commonly comorbid with ASD, including olfactory impairments, anxiety and delays in motor development. Here we investigate these features in an animal model related to ASD—the DVD-deficient rat. Compared to controls, both DVD-deficient male and female pups show altered ultrasonic vocalizations and stereotyped repetitive behavior. Further, the DVD-deficient animals had delayed motor development and impaired motor control. Adolescent DVD-deficient animals had impaired reciprocal social interaction, while as adults, these animals were hyperactive. The DVD-deficient model is associated with a range of behavioral features of interest to ASD.
topic	Vitamin D autism spectrum disorder behavior brain development animal model ultrasonic vocalizations
url	https://www.mdpi.com/2072-6643/11/5/1187
work_keys_str_mv	AT asadali developmentalvitaminddeficiencyproducesbehavioralphenotypesofrelevancetoautisminananimalmodel AT svetlinavasileva developmentalvitaminddeficiencyproducesbehavioralphenotypesofrelevancetoautisminananimalmodel AT mialangguth developmentalvitaminddeficiencyproducesbehavioralphenotypesofrelevancetoautisminananimalmodel AT suzannealexander developmentalvitaminddeficiencyproducesbehavioralphenotypesofrelevancetoautisminananimalmodel AT xiaoyingcui developmentalvitaminddeficiencyproducesbehavioralphenotypesofrelevancetoautisminananimalmodel AT andrewwhitehouse developmentalvitaminddeficiencyproducesbehavioralphenotypesofrelevancetoautisminananimalmodel AT johnjmcgrath developmentalvitaminddeficiencyproducesbehavioralphenotypesofrelevancetoautisminananimalmodel AT darryleyles developmentalvitaminddeficiencyproducesbehavioralphenotypesofrelevancetoautisminananimalmodel
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Developmental Vitamin D Deficiency Produces Behavioral Phenotypes of Relevance to Autism in an Animal Model

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