The Participation of Microglia in Neurogenesis: A Review

• Main Authors: Diego R. Pérez-Rodríguez, Idoia Blanco-Luquin, Maite Mendioroz
• Format: Article
• Language: English
• Published: MDPI AG 2021-05-01
• Series: Brain Sciences
• Subjects: microglia; inflammation; adult neurogenesis; age; neurodegenerative diseases
• Online Access: https://www.mdpi.com/2076-3425/11/5/658

Adult neurogenesis was one of the most important discoveries of the last century, helping us to better understand brain function. Researchers recently discovered that microglia play an important role in this process. However, various questions remain concerning where, at what stage, and what types of microglia participate. In this review, we demonstrate that certain pools of microglia are determinant cells in different phases of the generation of new neurons. This sheds light on how cells cooperate in order to fine tune brain organization. It also provides us with a better understanding of distinct neuronal pathologies.