The Participation of Microglia in Neurogenesis: A Review

Adult neurogenesis was one of the most important discoveries of the last century, helping us to better understand brain function. Researchers recently discovered that microglia play an important role in this process. However, various questions remain concerning where, at what stage, and what types o...

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Bibliographic Details
Main Authors: Diego R. Pérez-Rodríguez, Idoia Blanco-Luquin, Maite Mendioroz
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Brain Sciences
Subjects:
age
Online Access:https://www.mdpi.com/2076-3425/11/5/658
Description
Summary:Adult neurogenesis was one of the most important discoveries of the last century, helping us to better understand brain function. Researchers recently discovered that microglia play an important role in this process. However, various questions remain concerning where, at what stage, and what types of microglia participate. In this review, we demonstrate that certain pools of microglia are determinant cells in different phases of the generation of new neurons. This sheds light on how cells cooperate in order to fine tune brain organization. It also provides us with a better understanding of distinct neuronal pathologies.
ISSN:2076-3425