C0818, a novel curcumin derivative, interacts with Hsp90 and inhibits Hsp90 ATPase activity

C0818, a novel curcumin derivative, interacts with Hsp90 and inhibits Hsp90 ATPase activity

The aims of the present study were to estimate the affinity between 3,5-(E)-bis(3-methoxy-4-hydroxybenzal)-4-piperidinone hydrochloride (C0818) and heat shock protein 90 (Hsp90) and to investigate the inhibitory effects of this compound on Hsp90 ATPase activity. Fluorescence spectroscopy was used to...

Full description

Bibliographic Details
Main Authors: Yingjuan Fan, Yang Liu, Lianru Zhang, Fang Cai, Liping Zhu, Jianhua Xu
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Curcumin derivative
Hsp90
ATPase activity
Fluorescence spectrometry
Interaction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383516300260

Similar Items

Similar Items