Constellation Map: Downstream visualization and interpretation of gene set enrichment results [version 1; referees: 2 approved]

Constellation Map: Downstream visualization and interpretation of gene set enrichment results [version 1; referees: 2 approved]

Summary: Gene set enrichment analysis (GSEA) approaches are widely used to identify coordinately regulated genes associated with phenotypes of interest. Here, we present Constellation Map, a tool to visualize and interpret the results when enrichment analyses yield a long list of significantly enric...

Full description

Bibliographic Details
Main Authors: Yan Tan, Felix Wu, Pablo Tamayo, W. Nicholas Haining, Jill P. Mesirov
Format: Article
Language:English
Published: F1000 Research Ltd 2015-06-01
Series:F1000Research
Subjects:
Bioinformatics
Genetics of the Immune System
Genomics
Theory & Simulation
Online Access:http://f1000research.com/articles/4-167/v1
Description
Summary:Summary: Gene set enrichment analysis (GSEA) approaches are widely used to identify coordinately regulated genes associated with phenotypes of interest. Here, we present Constellation Map, a tool to visualize and interpret the results when enrichment analyses yield a long list of significantly enriched gene sets. Constellation Map identifies commonalities that explain the enrichment of multiple top-scoring gene sets and maps the relationships between them. Constellation Map can help investigators take full advantage of GSEA and facilitates the biological interpretation of enrichment results. Availability: Constellation Map is freely available as a GenePattern module at http://www.genepattern.org.
ISSN:2046-1402

Similar Items