Severe necrotising inflammatory skin reaction to topical 5-fluorouracil

Severe necrotising inflammatory skin reaction to topical 5-fluorouracil

I report two patients who developed a severe necrotising inflammatory skin reaction with ulceration and hemorrhagic crusting during the first cycle of chemotherapy with 1% 5-Fluorouracil eye drops for Ocular surface squamous neoplasia. The skin reaction subsided on stoppage of the drops and the use...

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Main Author: Nikhil S Gokhale
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Indian Journal of Ophthalmology
Subjects:
5-fluorouracil
inflammation
ocular surface squamous neoplasia
Online Access:http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=12;spage=2066;epage=2068;aulast=Gokhale
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spelling doaj-cf82b5dfb801496591347c2c166ecda52020-11-25T00:44:09ZengWolters Kluwer Medknow PublicationsIndian Journal of Ophthalmology0301-47381998-36892019-01-0167122066206810.4103/ijo.IJO_373_19Severe necrotising inflammatory skin reaction to topical 5-fluorouracilNikhil S GokhaleI report two patients who developed a severe necrotising inflammatory skin reaction with ulceration and hemorrhagic crusting during the first cycle of chemotherapy with 1% 5-Fluorouracil eye drops for Ocular surface squamous neoplasia. The skin reaction subsided on stoppage of the drops and the use of a steroid ointment. 5 fluorouracil therapy was terminated and the patients were shifted to interferon therapy subsequently.http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=12;spage=2066;epage=2068;aulast=Gokhale5-fluorouracilinflammationocular surface squamous neoplasia
collection DOAJ
language English
format Article
sources DOAJ
author Nikhil S Gokhale
spellingShingle Nikhil S Gokhale
Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
Indian Journal of Ophthalmology
5-fluorouracil
inflammation
ocular surface squamous neoplasia
author_facet Nikhil S Gokhale
author_sort Nikhil S Gokhale
title Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title_short Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title_full Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title_fullStr Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title_full_unstemmed Severe necrotising inflammatory skin reaction to topical 5-fluorouracil
title_sort severe necrotising inflammatory skin reaction to topical 5-fluorouracil
publisher Wolters Kluwer Medknow Publications
series Indian Journal of Ophthalmology
issn 0301-4738
1998-3689
publishDate 2019-01-01
description I report two patients who developed a severe necrotising inflammatory skin reaction with ulceration and hemorrhagic crusting during the first cycle of chemotherapy with 1% 5-Fluorouracil eye drops for Ocular surface squamous neoplasia. The skin reaction subsided on stoppage of the drops and the use of a steroid ointment. 5 fluorouracil therapy was terminated and the patients were shifted to interferon therapy subsequently.
topic 5-fluorouracil
inflammation
ocular surface squamous neoplasia
url http://www.ijo.in/article.asp?issn=0301-4738;year=2019;volume=67;issue=12;spage=2066;epage=2068;aulast=Gokhale
work_keys_str_mv AT nikhilsgokhale severenecrotisinginflammatoryskinreactiontotopical5fluorouracil
_version_ 1725276099874652160

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