Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion

Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion

Trophoblasts play a critical role in maintaining immunological tolerance at maternal–fetal interface. Here the authors show that IL-35 is made by trophoblasts, converts T cells to immune tolerant iTR35 cells, and is critical to prevent spontaneous abortion.

Bibliographic Details
Main Authors: Jia Liu, Shengnan Hao, Xi Chen, Hui Zhao, Lutao Du, Hanxiao Ren, Chuanxin Wang, Haiting Mao
Format: Article
Language:English
Published: Nature Publishing Group 2019-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12484-z
id doaj-cf7fe7edd61849c6b26a95d6606caef6
record_format Article
spelling doaj-cf7fe7edd61849c6b26a95d6606caef62021-05-11T12:04:32ZengNature Publishing GroupNature Communications2041-17232019-10-0110111010.1038/s41467-019-12484-zHuman placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversionJia Liu0Shengnan Hao1Xi Chen2Hui Zhao3Lutao Du4Hanxiao Ren5Chuanxin Wang6Haiting Mao7Department of Clinical Laboratory, The Second Hospital of Shandong UniversityDepartment of Clinical Laboratory, The Second Hospital of Shandong UniversityDepartment of Clinical Laboratory, The Second Hospital of Shandong UniversityDepartment of Clinical Laboratory, The Second Hospital of Shandong UniversityDepartment of Clinical Laboratory, The Second Hospital of Shandong UniversityDepartment of Clinical Laboratory, The Second Hospital of Shandong UniversityDepartment of Clinical Laboratory, The Second Hospital of Shandong UniversityDepartment of Clinical Laboratory, The Second Hospital of Shandong UniversityTrophoblasts play a critical role in maintaining immunological tolerance at maternal–fetal interface. Here the authors show that IL-35 is made by trophoblasts, converts T cells to immune tolerant iTR35 cells, and is critical to prevent spontaneous abortion.https://doi.org/10.1038/s41467-019-12484-z
collection DOAJ
language English
format Article
sources DOAJ
author Jia Liu
Shengnan Hao
Xi Chen
Hui Zhao
Lutao Du
Hanxiao Ren
Chuanxin Wang
Haiting Mao
spellingShingle Jia Liu
Shengnan Hao
Xi Chen
Hui Zhao
Lutao Du
Hanxiao Ren
Chuanxin Wang
Haiting Mao
Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
Nature Communications
author_facet Jia Liu
Shengnan Hao
Xi Chen
Hui Zhao
Lutao Du
Hanxiao Ren
Chuanxin Wang
Haiting Mao
author_sort Jia Liu
title Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
title_short Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
title_full Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
title_fullStr Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
title_full_unstemmed Human placental trophoblast cells contribute to maternal–fetal tolerance through expressing IL-35 and mediating iTR35 conversion
title_sort human placental trophoblast cells contribute to maternal–fetal tolerance through expressing il-35 and mediating itr35 conversion
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-10-01
description Trophoblasts play a critical role in maintaining immunological tolerance at maternal–fetal interface. Here the authors show that IL-35 is made by trophoblasts, converts T cells to immune tolerant iTR35 cells, and is critical to prevent spontaneous abortion.
url https://doi.org/10.1038/s41467-019-12484-z
work_keys_str_mv AT jialiu humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT shengnanhao humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT xichen humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT huizhao humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT lutaodu humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT hanxiaoren humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT chuanxinwang humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
AT haitingmao humanplacentaltrophoblastcellscontributetomaternalfetaltolerancethroughexpressingil35andmediatingitr35conversion
_version_ 1721445544219377664

Similar Items