Rare case of bilateral vassal agenesis and AZFc microdeletion: A case report

Introduction: Bilateral vassal agenesis (CBAVD) is a rare cause of male infertility. Also one of the nonobstructive cause of azoospermia and infertility in men is microdeletion in long arm of Y chromosome. In this case report we have reported a rare case of CBAVD, LT renal agenesis and AZFc microdel...

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Main Authors: Mohammad Ali Sadighi Gilani, Hesamoddin Sajadi
Format: Article
Language:English
Published: Shahid Beheshti University of Medical Sciences 2018-07-01
Series:Men's Health Journal
Online Access:https://journals.sbmu.ac.ir/index.php/mhj/article/view/22121
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spelling doaj-cf7ce27d7d674038b72f0feb3dbda2c52021-01-26T05:47:46ZengShahid Beheshti University of Medical SciencesMen's Health Journal2645-36142018-07-0121e3e310.22037/mhj.v2i1.2212122121Rare case of bilateral vassal agenesis and AZFc microdeletion: A case reportMohammad Ali Sadighi GilaniHesamoddin SajadiIntroduction: Bilateral vassal agenesis (CBAVD) is a rare cause of male infertility. Also one of the nonobstructive cause of azoospermia and infertility in men is microdeletion in long arm of Y chromosome. In this case report we have reported a rare case of CBAVD, LT renal agenesis and AZFc microdeletion. Patient Information: 28 years old man, who was farmer with history of 6 years of infertility presented to our andrology clinic in Royan institute. In physical examination there was not any palpable vas deferens bilaterally, also The semen analysis was azoospermia. In sonographic evaluation, LT kidney wasn’t seen in its anatomic location. The patient candidate for diagnostic PESA and bilateral PESA were negative. After that, the patient candidate for bilateral TESE and fascinatingly TESE was negative too. After genetic evaluation microdeletion was detected in AZFc subregion of Y chromosome. Conclusion: In men with obstructive azoospermia mostly testicular spermatogenesis is normal but this is not the rule because seldom spermatogenic dysfunction maybe present like our patient. We emphasize about the importance of consideration of obstructive and nonobstructive azoospermia together in a patient for urologists.https://journals.sbmu.ac.ir/index.php/mhj/article/view/22121
collection DOAJ
language English
format Article
sources DOAJ
author Mohammad Ali Sadighi Gilani
Hesamoddin Sajadi
spellingShingle Mohammad Ali Sadighi Gilani
Hesamoddin Sajadi
Rare case of bilateral vassal agenesis and AZFc microdeletion: A case report
Men's Health Journal
author_facet Mohammad Ali Sadighi Gilani
Hesamoddin Sajadi
author_sort Mohammad Ali Sadighi Gilani
title Rare case of bilateral vassal agenesis and AZFc microdeletion: A case report
title_short Rare case of bilateral vassal agenesis and AZFc microdeletion: A case report
title_full Rare case of bilateral vassal agenesis and AZFc microdeletion: A case report
title_fullStr Rare case of bilateral vassal agenesis and AZFc microdeletion: A case report
title_full_unstemmed Rare case of bilateral vassal agenesis and AZFc microdeletion: A case report
title_sort rare case of bilateral vassal agenesis and azfc microdeletion: a case report
publisher Shahid Beheshti University of Medical Sciences
series Men's Health Journal
issn 2645-3614
publishDate 2018-07-01
description Introduction: Bilateral vassal agenesis (CBAVD) is a rare cause of male infertility. Also one of the nonobstructive cause of azoospermia and infertility in men is microdeletion in long arm of Y chromosome. In this case report we have reported a rare case of CBAVD, LT renal agenesis and AZFc microdeletion. Patient Information: 28 years old man, who was farmer with history of 6 years of infertility presented to our andrology clinic in Royan institute. In physical examination there was not any palpable vas deferens bilaterally, also The semen analysis was azoospermia. In sonographic evaluation, LT kidney wasn’t seen in its anatomic location. The patient candidate for diagnostic PESA and bilateral PESA were negative. After that, the patient candidate for bilateral TESE and fascinatingly TESE was negative too. After genetic evaluation microdeletion was detected in AZFc subregion of Y chromosome. Conclusion: In men with obstructive azoospermia mostly testicular spermatogenesis is normal but this is not the rule because seldom spermatogenic dysfunction maybe present like our patient. We emphasize about the importance of consideration of obstructive and nonobstructive azoospermia together in a patient for urologists.
url https://journals.sbmu.ac.ir/index.php/mhj/article/view/22121
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