Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival

Multiple functions of precursor BDNF to CNS neurons: negative regulation of neurite growth, spine formation and cell survival

<p>Abstract</p> <p>Background</p> <p>Proneurotrophins and mature neurotrophins elicit opposite effects via the p75 neurotrophin receptor (p75<sup>NTR</sup>) and Trk tyrosine kinase receptors, respectively; however the molecular roles of proneurotrophins in t...

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Main Authors: Koshimizu Hisatsugu, Kiyosue Kazuyuki, Hara Tomoko, Hazama Shunsuke, Suzuki Shingo, Uegaki Koichi, Nagappan Guhan, Zaitsev Eugene, Hirokawa Takatsugu, Tatsu Yoshiro, Ogura Akihiko, Lu Bai, Kojima Masami
Format: Article
Language:English
Published: BMC 2009-08-01
Series:Molecular Brain
Online Access:http://www.molecularbrain.com/content/2/1/27

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