Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies

Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies

Many<b> </b>proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation. IDRs are increasingly recognized as critical elements of regulatory networks and have been also associated with cancer. However,...

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Bibliographic Details
Main Authors: Bálint Mészáros, Borbála Hajdu-Soltész, András Zeke, Zsuzsanna Dosztányi
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomolecules
Subjects:
intrinsically disordered regions
protein modules
short linear motifs
molecular switches
cancer genomics
driver gene identification
Online Access:https://www.mdpi.com/2218-273X/11/3/381

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