Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer

Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer

The immune response crucially determines the survival of patients with malignant tumors including breast carcinoma. The aim of the present study was to evaluate retrospectively an association of peripheral blood cell count (PBC)-derived ratios and urinary neopterin concentration with prognosis in br...

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Main Authors: Melichar Bohuslav, Študentová Hana, Vitásková Denisa, Šrámek Vlastislav, Kujovská Krčmová Lenka, Pešková Eliška, Solichová Dagmar, Kalábová Hana, Ryška Aleš, Hrůzová Klára, Havlík Roman
Format: Article
Language:English
Published: De Gruyter 2016-12-01
Series:Pteridines
Subjects:
breast cancer
lymphocyte-to-monocyte ratio
neopterin
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
Online Access:https://doi.org/10.1515/pterid-2016-0001
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spelling doaj-cf5cc9ac360c4b1999df32830f4666bd2021-09-05T13:59:56ZengDe GruyterPteridines0933-48072195-47202016-12-01273-4596510.1515/pterid-2016-0001Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancerMelichar Bohuslav0Študentová Hana1Vitásková Denisa2Šrámek Vlastislav3Kujovská Krčmová Lenka4Pešková Eliška5Solichová Dagmar6Kalábová Hana7Ryška Aleš8Hrůzová Klára9Havlík Roman10Department of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicDepartment of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicDepartment of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicDepartment of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicThird Department of Medicine, Charles University Teaching Hospital, Sokolská 581, 500 05 Hradec Králové, Czech RepublicFourth Department of Medicine, Charles University Teaching Hospital, Sokolská 581, 500 05 Hradec Králové, Czech RepublicThird Department of Medicine, Charles University Teaching Hospital, Sokolská 581, 500 05 Hradec Králové, Czech RepublicDepartment of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicThe Fingerland Department of Pathology, Charles University Medical School and Teaching Hospital, Sokolská 581, 500 05 Hradec Králové, Czech RepublicDepartment of Oncology, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicDepartment of Surgery, Palacký University Medical School and Teaching Hospital, I.P. Pavlova 6, 779 00 Olomouc, Czech RepublicThe immune response crucially determines the survival of patients with malignant tumors including breast carcinoma. The aim of the present study was to evaluate retrospectively an association of peripheral blood cell count (PBC)-derived ratios and urinary neopterin concentration with prognosis in breast cancer patients. Urinary neopterin, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) were retrospectively analyzed in a cohort of 474 breast cancer patients. NLR and PLR correlated positively with each other and negatively with LMR, but no correlation between neopterin concentrations and PBC-derived ratios was observed. Increased urinary neopterin concentration was a significant predictor of poor survival in patients with active disease, but PLR, NLR or LMR were not significantly associated with survival in multivariate analysis. In conclusion, increased urinary neopterin was a significant predictor of poor survival in patients with breast cancer and active disease.https://doi.org/10.1515/pterid-2016-0001breast cancerlymphocyte-to-monocyte rationeopterinneutrophil-to-lymphocyte ratioplatelet-to-lymphocyte ratio
collection DOAJ
language English
format Article
sources DOAJ
author Melichar Bohuslav
Študentová Hana
Vitásková Denisa
Šrámek Vlastislav
Kujovská Krčmová Lenka
Pešková Eliška
Solichová Dagmar
Kalábová Hana
Ryška Aleš
Hrůzová Klára
Havlík Roman
spellingShingle Melichar Bohuslav
Študentová Hana
Vitásková Denisa
Šrámek Vlastislav
Kujovská Krčmová Lenka
Pešková Eliška
Solichová Dagmar
Kalábová Hana
Ryška Aleš
Hrůzová Klára
Havlík Roman
Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer
Pteridines
breast cancer
lymphocyte-to-monocyte ratio
neopterin
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
author_facet Melichar Bohuslav
Študentová Hana
Vitásková Denisa
Šrámek Vlastislav
Kujovská Krčmová Lenka
Pešková Eliška
Solichová Dagmar
Kalábová Hana
Ryška Aleš
Hrůzová Klára
Havlík Roman
author_sort Melichar Bohuslav
title Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer
title_short Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer
title_full Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer
title_fullStr Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer
title_full_unstemmed Association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer
title_sort association of urinary neopterin, neutrophil-to-lymphocyte, lymphocyte-to-monocyte and platelet-to-lymphocyte ratios with long-term survival of patients with breast cancer
publisher De Gruyter
series Pteridines
issn 0933-4807
2195-4720
publishDate 2016-12-01
description The immune response crucially determines the survival of patients with malignant tumors including breast carcinoma. The aim of the present study was to evaluate retrospectively an association of peripheral blood cell count (PBC)-derived ratios and urinary neopterin concentration with prognosis in breast cancer patients. Urinary neopterin, neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR) and platelet-to-lymphocyte ratio (PLR) were retrospectively analyzed in a cohort of 474 breast cancer patients. NLR and PLR correlated positively with each other and negatively with LMR, but no correlation between neopterin concentrations and PBC-derived ratios was observed. Increased urinary neopterin concentration was a significant predictor of poor survival in patients with active disease, but PLR, NLR or LMR were not significantly associated with survival in multivariate analysis. In conclusion, increased urinary neopterin was a significant predictor of poor survival in patients with breast cancer and active disease.
topic breast cancer
lymphocyte-to-monocyte ratio
neopterin
neutrophil-to-lymphocyte ratio
platelet-to-lymphocyte ratio
url https://doi.org/10.1515/pterid-2016-0001
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