IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection

IFN-γ and IL-5 whole blood response directed against mycolactone polyketide synthase domains in patients with Mycobacterium ulcerans infection

Background Buruli ulcer is a disease of the skin and soft tissues caused by infection with a slow growing pathogen, Mycobacterium ulcerans. A vaccine for this disease is not available but M. ulcerans possesses a giant plasmid pMUM001 that harbours the polyketide synthase (PKS) genes encoding a multi...

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Bibliographic Details
Main Authors: Aloysius D. Loglo, Michael Frimpong, Mabel Sarpong Duah, Fred Sarfo, Francisca N. Sarpong, Bernadette Agbavor, Justice K. Boakye-Appiah, Kabiru M. Abass, Mathias Dongyele, Margaret Frempong, Sacha Pidot, Mark Wansbrough-Jones, Timothy P. Stinear, Virginie Roupie, Kris Huygen, Richard O. Phillips
Format: Article
Language:English
Published: PeerJ Inc. 2018-07-01
Series:PeerJ
Subjects:
Mycobacterium ulcerans
Immune response
Polyketide synthase domains
Buruli ulcer
Online Access:https://peerj.com/articles/5294.pdf

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