Effects of Xiaocangping tablets combined with 5-fluorouracil and cisplatin on immunity, tumor markers, angiogenesis and related factors in patients with advanced esophageal cancer

• Main Authors: Zhi-Liang Yang, Peng Zhang, Zhi-Ming Tan, Zhi-Zhong Pu
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-04-01
• Series: Journal of Hainan Medical University
• Subjects: xiaocangping; 5-fluorouracil+cisplatin; advanced esophageal cancer; immunity; tumor markers; angiogenesis; related factors
• Online Access: http://www.hnykdxxb.com/PDF/201908/15.pdf

Objective: To explore the effects of Xiaocangping tablets combined with 5-fluorouracil and cisplatin on immunity, tumor markers, angiogenesis and related factors in patients with advanced esophageal cancer. Methods: 86 patients with advanced esophageal cancer admitted to our hospital from March 2014 to February 2017 were randomly divided into control group (43 cases) and observation group (43 cases). All the subjects were treated with 5-fluorouracil plus cisplatin, and the observation group was treated with Xiaocangping tablets on this basis. The changes of immune function, tumor markers, angiogenesis and related factors in the two groups were compared and analyzed. Results: After treatment, the levels of CD4+, CD4+/ CD8 + in both groups were significantly higher than those before treatment (P<0.05), while the levels of CD8+ were significantly lower than those before treatment (P<0.05), the levels of CD4+ and CD4+/CD8+ in the observation group were significantly higher than those in the control group (P<0.05), while the levels of CD8+ in the observation group was significantly lower than that in the control group (P<0.05); the levels of CA125, CEA and CA19-9 in the two groups were significantly lower than those before treatment (P<0.05), and the levels of CA125, CEA and CA19-9 in the observation group were significantly lower than those in the control group (P<0.05); the levels of VEGF, TGF-β1, MMP-9, NGAL in the two groups were significantly lower than those before treatment (P<0.05), and the levels of VEGF, TGF- β1, MMP-9, NGAL in the observation group were significantly lower than the control group (P<0.05). Conclusions: Chemotherapy combined with fluorouracil + cisplatin chemotherapy for advanced esophageal cancer can effectively improve the immune function of patients, reduce the level of tumor markers, inhibit the proliferation of tumor blood vessels, and have significant anti-cancer effects, which is of positive significance for controlling the development of patients’ conditions.