Markers of Oxidative Stress and Neuroprogression in Depression Disorder

Major depression is multifactorial disorder with high prevalence and alarming prognostic in the nearest 15 years. Several mechanisms of depression are known. Neurotransmitters imbalance and imbalance between neuroprogressive and neuroprotective factors are observed in major depression. Depression is...

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Main Authors: Magdaléna Vaváková, Zdeňka Ďuračková, Jana Trebatická
Format: Article
Language:English
Published: Hindawi Limited 2015-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2015/898393
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spelling doaj-cf38870b59a349c29d6e13ce37a7f6332020-11-24T21:32:40ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942015-01-01201510.1155/2015/898393898393Markers of Oxidative Stress and Neuroprogression in Depression DisorderMagdaléna Vaváková0Zdeňka Ďuračková1Jana Trebatická2Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava, SlovakiaInstitute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Sasinkova 2, 813 72 Bratislava, SlovakiaDepartment of Pediatric Psychiatry, Medical Faculty, Comenius University and Child University Hospital, Faculty of Medicine, University Hospital, Limbová 1, 833 40 Bratislava, SlovakiaMajor depression is multifactorial disorder with high prevalence and alarming prognostic in the nearest 15 years. Several mechanisms of depression are known. Neurotransmitters imbalance and imbalance between neuroprogressive and neuroprotective factors are observed in major depression. Depression is accompanied by inflammatory responses of the organism and consequent elevation of proinflammatory cytokines and increased lipid peroxidation are described in literature. Neuropsychiatric disorders including major depression are also associated with telomerase shortening, oxidative changes in nucleotides, and polymorphisms in several genes connected to metabolism of reactive oxygen species. Mitochondrion dysfunction is directly associated with increasing levels of oxidative stress. Oxidative stress plays significant role in pathophysiology of major depression via actions of free radicals, nonradical molecules, and reactive oxygen and nitrogen species. Products of oxidative stress represent important parameters for measuring and predicting of depression status as well as for determining effectiveness of administrated antidepressants. Positive effect of micronutrients, vitamins, and antioxidants in depression treatment is also reviewed.http://dx.doi.org/10.1155/2015/898393
collection DOAJ
language English
format Article
sources DOAJ
author Magdaléna Vaváková
Zdeňka Ďuračková
Jana Trebatická
spellingShingle Magdaléna Vaváková
Zdeňka Ďuračková
Jana Trebatická
Markers of Oxidative Stress and Neuroprogression in Depression Disorder
Oxidative Medicine and Cellular Longevity
author_facet Magdaléna Vaváková
Zdeňka Ďuračková
Jana Trebatická
author_sort Magdaléna Vaváková
title Markers of Oxidative Stress and Neuroprogression in Depression Disorder
title_short Markers of Oxidative Stress and Neuroprogression in Depression Disorder
title_full Markers of Oxidative Stress and Neuroprogression in Depression Disorder
title_fullStr Markers of Oxidative Stress and Neuroprogression in Depression Disorder
title_full_unstemmed Markers of Oxidative Stress and Neuroprogression in Depression Disorder
title_sort markers of oxidative stress and neuroprogression in depression disorder
publisher Hindawi Limited
series Oxidative Medicine and Cellular Longevity
issn 1942-0900
1942-0994
publishDate 2015-01-01
description Major depression is multifactorial disorder with high prevalence and alarming prognostic in the nearest 15 years. Several mechanisms of depression are known. Neurotransmitters imbalance and imbalance between neuroprogressive and neuroprotective factors are observed in major depression. Depression is accompanied by inflammatory responses of the organism and consequent elevation of proinflammatory cytokines and increased lipid peroxidation are described in literature. Neuropsychiatric disorders including major depression are also associated with telomerase shortening, oxidative changes in nucleotides, and polymorphisms in several genes connected to metabolism of reactive oxygen species. Mitochondrion dysfunction is directly associated with increasing levels of oxidative stress. Oxidative stress plays significant role in pathophysiology of major depression via actions of free radicals, nonradical molecules, and reactive oxygen and nitrogen species. Products of oxidative stress represent important parameters for measuring and predicting of depression status as well as for determining effectiveness of administrated antidepressants. Positive effect of micronutrients, vitamins, and antioxidants in depression treatment is also reviewed.
url http://dx.doi.org/10.1155/2015/898393
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