Revealing biomarkers associated with PARP inhibitors based on genetic interactions in cancer genome

Revealing biomarkers associated with PARP inhibitors based on genetic interactions in cancer genome

Poly (ADPribose) polymerase inhibitors (PARPis) are clinically approved drugs designed according to the concept of synthetic lethality (SL) interaction. It is crucial to expand the scale of patients who can benefit from PARPis, and overcome drug resistance associated with it. Genetic interactions (G...

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Bibliographic Details
Main Authors: Qi Dong, Mingyue Liu, Bo Chen, Zhangxiang Zhao, Tingting Chen, Chengyu Wang, Shuping Zhuang, Yawei Li, Yuquan Wang, Liqiang Ai, Yaoyao Liu, Haihai Liang, Lishuang Qi, Yunyan Gu
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
PARP inhibitors
Genetic interactions
Mutation
Resistant biomarkers
Sensitive biomarkers
Online Access:http://www.sciencedirect.com/science/article/pii/S200103702100338X

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