A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages.

A polymorphic residue that attenuates the antiviral potential of interferon lambda 4 in hominid lineages.

As antimicrobial signalling molecules, type III or lambda interferons (IFNλs) are critical for defence against infection by diverse pathogens, including bacteria, fungi and viruses. Counter-intuitively, expression of one member of the family, IFNλ4, is associated with decreased clearance of hepatiti...

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Bibliographic Details
Main Authors: Connor G G Bamford, Elihu Aranday-Cortes, Ines Cordeiro Filipe, Swathi Sukumar, Daniel Mair, Ana da Silva Filipe, Juan L Mendoza, K Christopher Garcia, Shaohua Fan, Sarah A Tishkoff, John McLauchlan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC6181419?pdf=render

Internet

http://europepmc.org/articles/PMC6181419?pdf=render

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