WT1 Enhances Proliferation and Impedes Apoptosis in KRAS Mutant NSCLC via Targeting cMyc

WT1 Enhances Proliferation and Impedes Apoptosis in KRAS Mutant NSCLC via Targeting cMyc

Background: A novel link between oncogenic KRAS signalling and WT1 was recently identified. We sought to investigate the role of WT1 and KRAS in proliferation and apoptosis. Methods: KRAS mutations and WT1 (cMyc) expression were detected using Sanger sequencing and real-time PCR in 77 patients with...

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Bibliographic Details
Main Authors: Chen Wu, Sihan Wang, Caihua Xu, Andreas Tyler, Xingru Li, Charlotta Andersson, Yusuke Oji, Haruo Sugiyama, Yijiang Chen, Aihong Li
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-01-01
Series:Cellular Physiology and Biochemistry
Subjects:
WT1
cMyc
NSCLC
Apoptosis
KRAS mutation
Online Access:http://www.karger.com/Article/FullText/369726

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