T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics.

T-cell responses to sequentially emerging viral escape mutants shape long-term HIV-1 population dynamics.

HIV-1 strains harboring immune escape mutations can persist in circulation, but the impact of selection by multiple HLA alleles on population HIV-1 dynamics remains unclear. In Japan, HIV-1 Reverse Transcriptase codon 135 (RT135) is under strong immune pressure by HLA-B*51:01-restricted and HLA-B*52...

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Bibliographic Details
Main Authors: Tomohiro Akahoshi, Hiroyuki Gatanaga, Nozomi Kuse, Takayuki Chikata, Madoka Koyanagi, Naoki Ishizuka, Chanson J Brumme, Hayato Murakoshi, Zabrina L Brumme, Shinichi Oka, Masafumi Takiguchi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-12-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009177

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