Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues

Cardiomyocytes derived from human induced pluripotent stem cells could be used to generate cardiac tissues for regenerative purposes. Here the authors describe a method to obtain large bioengineered heart tissues showing advanced maturation, functional features and engraftment capacity.

Bibliographic Details
Main Authors: Ilya Y. Shadrin, Brian W. Allen, Ying Qian, Christopher P. Jackman, Aaron L. Carlson, Mark E. Juhas, Nenad Bursac
Format: Article
Language:English
Published: Nature Publishing Group 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01946-x
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spelling doaj-cf30a3c33e6d47d2acb195744c55d7712021-05-11T07:38:21ZengNature Publishing GroupNature Communications2041-17232017-11-018111510.1038/s41467-017-01946-xCardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissuesIlya Y. Shadrin0Brian W. Allen1Ying Qian2Christopher P. Jackman3Aaron L. Carlson4Mark E. Juhas5Nenad Bursac6Department of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Duke UniversityCardiomyocytes derived from human induced pluripotent stem cells could be used to generate cardiac tissues for regenerative purposes. Here the authors describe a method to obtain large bioengineered heart tissues showing advanced maturation, functional features and engraftment capacity.https://doi.org/10.1038/s41467-017-01946-x
collection DOAJ
language English
format Article
sources DOAJ
author Ilya Y. Shadrin
Brian W. Allen
Ying Qian
Christopher P. Jackman
Aaron L. Carlson
Mark E. Juhas
Nenad Bursac
spellingShingle Ilya Y. Shadrin
Brian W. Allen
Ying Qian
Christopher P. Jackman
Aaron L. Carlson
Mark E. Juhas
Nenad Bursac
Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
Nature Communications
author_facet Ilya Y. Shadrin
Brian W. Allen
Ying Qian
Christopher P. Jackman
Aaron L. Carlson
Mark E. Juhas
Nenad Bursac
author_sort Ilya Y. Shadrin
title Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
title_short Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
title_full Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
title_fullStr Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
title_full_unstemmed Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
title_sort cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-11-01
description Cardiomyocytes derived from human induced pluripotent stem cells could be used to generate cardiac tissues for regenerative purposes. Here the authors describe a method to obtain large bioengineered heart tissues showing advanced maturation, functional features and engraftment capacity.
url https://doi.org/10.1038/s41467-017-01946-x
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AT brianwallen cardiopatchplatformenablesmaturationandscaleupofhumanpluripotentstemcellderivedengineeredhearttissues
AT yingqian cardiopatchplatformenablesmaturationandscaleupofhumanpluripotentstemcellderivedengineeredhearttissues
AT christopherpjackman cardiopatchplatformenablesmaturationandscaleupofhumanpluripotentstemcellderivedengineeredhearttissues
AT aaronlcarlson cardiopatchplatformenablesmaturationandscaleupofhumanpluripotentstemcellderivedengineeredhearttissues
AT markejuhas cardiopatchplatformenablesmaturationandscaleupofhumanpluripotentstemcellderivedengineeredhearttissues
AT nenadbursac cardiopatchplatformenablesmaturationandscaleupofhumanpluripotentstemcellderivedengineeredhearttissues
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