Trefoil factors share a lectin activity that defines their role in mucus

Trefoil factors (TFFs) protect the mucosa and have various reported binding activities, but whether they share a common interaction mechanism has remained unclear. Here, the authors provide structural and biochemical evidence that all three human TFFs are divalent lectins that recognise the same dis...

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Main Authors:	Michael A. Järvå, James P. Lingford, Alan John, Niccolay Madiedo Soler, Nichollas E. Scott, Ethan D. Goddard-Borger
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-05-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16223-7

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spelling	doaj-cf2cbf05a6394844b850bf051a2a39632021-05-16T11:12:17ZengNature Publishing GroupNature Communications2041-17232020-05-011111910.1038/s41467-020-16223-7Trefoil factors share a lectin activity that defines their role in mucusMichael A. Järvå0James P. Lingford1Alan John2Niccolay Madiedo Soler3Nichollas E. Scott4Ethan D. Goddard-Borger5The Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchThe Walter and Eliza Hall Institute of Medical ResearchDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and ImmunityThe Walter and Eliza Hall Institute of Medical ResearchTrefoil factors (TFFs) protect the mucosa and have various reported binding activities, but whether they share a common interaction mechanism has remained unclear. Here, the authors provide structural and biochemical evidence that all three human TFFs are divalent lectins that recognise the same disaccharide.https://doi.org/10.1038/s41467-020-16223-7
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Michael A. Järvå James P. Lingford Alan John Niccolay Madiedo Soler Nichollas E. Scott Ethan D. Goddard-Borger
spellingShingle	Michael A. Järvå James P. Lingford Alan John Niccolay Madiedo Soler Nichollas E. Scott Ethan D. Goddard-Borger Trefoil factors share a lectin activity that defines their role in mucus Nature Communications
author_facet	Michael A. Järvå James P. Lingford Alan John Niccolay Madiedo Soler Nichollas E. Scott Ethan D. Goddard-Borger
author_sort	Michael A. Järvå
title	Trefoil factors share a lectin activity that defines their role in mucus
title_short	Trefoil factors share a lectin activity that defines their role in mucus
title_full	Trefoil factors share a lectin activity that defines their role in mucus
title_fullStr	Trefoil factors share a lectin activity that defines their role in mucus
title_full_unstemmed	Trefoil factors share a lectin activity that defines their role in mucus
title_sort	trefoil factors share a lectin activity that defines their role in mucus
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-05-01
description	Trefoil factors (TFFs) protect the mucosa and have various reported binding activities, but whether they share a common interaction mechanism has remained unclear. Here, the authors provide structural and biochemical evidence that all three human TFFs are divalent lectins that recognise the same disaccharide.
url	https://doi.org/10.1038/s41467-020-16223-7
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Trefoil factors share a lectin activity that defines their role in mucus

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