PL201, a Reported Rhamnoside Against Alzheimer's Disease Pathology, Alleviates Neuroinflammation and Stimulates Nrf2 Signaling

PL201, a Reported Rhamnoside Against Alzheimer's Disease Pathology, Alleviates Neuroinflammation and Stimulates Nrf2 Signaling

Neuroinflammation induced by overactivated glia cells is believed to be a major hallmark of Alzheimer's disease (AD) and a hopeful target against AD. A rhamnoside PL201 was previously reported to promote neurogenesis and ameliorate AD, and in this study, we revealed that PL201 also significantl...

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Bibliographic Details
Main Authors: Yuqian An, Hong Zhang, Shichao Huang, Gang Pei
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Immunology
Subjects:
Alzheimer's disease
neuroinflammation
microglia
rhamnoside analog
nuclear factor erythroid 2-related factor 2
heme oxygenase 1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.00162/full

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