Aerobic Exercise Ameliorates Myocardial Inflammation, Fibrosis and Apoptosis in High-Fat-Diet Rats by Inhibiting P2X7 Purinergic Receptors

Aerobic Exercise Ameliorates Myocardial Inflammation, Fibrosis and Apoptosis in High-Fat-Diet Rats by Inhibiting P2X7 Purinergic Receptors

BackgroundHigh-fat-diet (HFD) is associated with chronic low-grade inflammation. P2X7 purinergic receptors (P2X7R) are key regulators of inflammasome activation. The benefits of exercise are partly attributed to its anti-inflammatory effect, but whether it regulates P2X7R expression to improve remod...

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Bibliographic Details
Main Authors: Xudong Chen, Haiyan Li, Kangwei Wang, Xiaohe Liang, Weiqi Wang, Xiaokang Hu, Zhouqing Huang, Yonghua Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-10-01
Series:Frontiers in Physiology
Subjects:
aerobic exercise
P2X7 purinergic receptors
high-fat-diet
inflammation
fibrosis
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01286/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2019.01286/full

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