Controlled in vivo Bone Formation and Vascularization Using Ultrasound-Triggered Release of Recombinant Vascular Endothelial Growth Factor From Poly(D,L-lactic-co-glycolicacid) Microbubbles

Controlled in vivo Bone Formation and Vascularization Using Ultrasound-Triggered Release of Recombinant Vascular Endothelial Growth Factor From Poly(D,L-lactic-co-glycolicacid) Microbubbles

Bone defects are challenging to treat in musculoskeletal system due to the lack of vascularization. Biomaterials with internal vascularization ability and osteoinduction bioactivity are promising strategies for orthopedic applications. Vascular endothelial growth factor (VEGF) has been widely used f...

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Bibliographic Details
Main Authors: Yong Gong, Songjian Li, Wei Zeng, Jianing Yu, Yan Chen, Bo Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
bone defect
vascular endothelial growth factor
angiogenesis
ultrasound
osteogenesis
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00413/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00413/full

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