A report of nine cases and review of the literature of infertile men carrying balanced translocations involving chromosome 5

A report of nine cases and review of the literature of infertile men carrying balanced translocations involving chromosome 5

Abstract Background Balanced translocations may cause the loss of genetic material at the breakpoints and may result in failure of spermatogenesis. However, carriers of reciprocal translocation may naturally conceive. Genetic counseling of male carriers of translocations remains challenging. This st...

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Bibliographic Details
Main Authors: Hong-Guo Zhang, Rui-Xue Wang, Yuan Pan, Han Zhang, Lei-Lei Li, Hai-Bo Zhu, Rui-Zhi Liu
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Molecular Cytogenetics
Subjects:
Male infertility
Chromosome 5
Balanced translocation
Breakpoint
Genetic counseling
Online Access:http://link.springer.com/article/10.1186/s13039-018-0360-x

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