Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma
Studying the spatial mutational and gene expression alterations in breast cancer could impact our understanding of breast cancer development. Here, the authors analyse a unique dataset of epithelial samples that highlight potential field cancerisation surrounding the primary tumour.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2017-11-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-01357-y |
| id |
doaj-ceecba4deac145a6bb91d719ca0af931 |
|---|---|
| record_format |
Article |
| spelling |
doaj-ceecba4deac145a6bb91d719ca0af9312021-05-11T07:30:40ZengNature Publishing GroupNature Communications2041-17232017-11-018111110.1038/s41467-017-01357-yMapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinomaMoustafa Abdalla0Danh Tran-Thanh1Juan Moreno2Vladimir Iakovlev3Ranju Nair4Nisha Kanwar5Mohamed Abdalla6Jennifer P. Y. Lee7Jennifer Yin Yee Kwan8Thomas R. Cawthorn9Keisha Warren10Nona Arneson11Dong-Yu Wang12Natalie S. Fox13Bruce J. Youngson14Naomi A. Miller15Alexandra M. Easson16David McCready17Wey L. Leong18Paul C. Boutros19Susan J. Done20Campbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health NetworkDepartment of Laboratory Medicine and Pathobiology, University of TorontoDepartment of Laboratory Medicine and Pathobiology, University of TorontoDepartment of Laboratory Medicine and Pathobiology, University of TorontoCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health NetworkCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health NetworkDepartment of Laboratory Medicine and Pathobiology, University of TorontoDepartment of Laboratory Medicine and Pathobiology, University of TorontoDepartment of Laboratory Medicine and Pathobiology, University of TorontoCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health NetworkCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health NetworkCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health NetworkCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health NetworkDepartment of Medical Biophysics, University of TorontoDepartment of Laboratory Medicine and Pathobiology, University of TorontoDepartment of Laboratory Medicine and Pathobiology, University of TorontoDepartment of Surgical Oncology, Princess Margaret Cancer Center and University of TorontoDepartment of Surgical Oncology, Princess Margaret Cancer Center and University of TorontoDepartment of Surgical Oncology, Princess Margaret Cancer Center and University of TorontoDepartment of Medical Biophysics, University of TorontoCampbell Family Institute for Breast Cancer Research, Princess Margaret Cancer Centre, University Health NetworkStudying the spatial mutational and gene expression alterations in breast cancer could impact our understanding of breast cancer development. Here, the authors analyse a unique dataset of epithelial samples that highlight potential field cancerisation surrounding the primary tumour.https://doi.org/10.1038/s41467-017-01357-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Moustafa Abdalla Danh Tran-Thanh Juan Moreno Vladimir Iakovlev Ranju Nair Nisha Kanwar Mohamed Abdalla Jennifer P. Y. Lee Jennifer Yin Yee Kwan Thomas R. Cawthorn Keisha Warren Nona Arneson Dong-Yu Wang Natalie S. Fox Bruce J. Youngson Naomi A. Miller Alexandra M. Easson David McCready Wey L. Leong Paul C. Boutros Susan J. Done |
| spellingShingle |
Moustafa Abdalla Danh Tran-Thanh Juan Moreno Vladimir Iakovlev Ranju Nair Nisha Kanwar Mohamed Abdalla Jennifer P. Y. Lee Jennifer Yin Yee Kwan Thomas R. Cawthorn Keisha Warren Nona Arneson Dong-Yu Wang Natalie S. Fox Bruce J. Youngson Naomi A. Miller Alexandra M. Easson David McCready Wey L. Leong Paul C. Boutros Susan J. Done Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma Nature Communications |
| author_facet |
Moustafa Abdalla Danh Tran-Thanh Juan Moreno Vladimir Iakovlev Ranju Nair Nisha Kanwar Mohamed Abdalla Jennifer P. Y. Lee Jennifer Yin Yee Kwan Thomas R. Cawthorn Keisha Warren Nona Arneson Dong-Yu Wang Natalie S. Fox Bruce J. Youngson Naomi A. Miller Alexandra M. Easson David McCready Wey L. Leong Paul C. Boutros Susan J. Done |
| author_sort |
Moustafa Abdalla |
| title |
Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma |
| title_short |
Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma |
| title_full |
Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma |
| title_fullStr |
Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma |
| title_full_unstemmed |
Mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma |
| title_sort |
mapping genomic and transcriptomic alterations spatially in epithelial cells adjacent to human breast carcinoma |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-11-01 |
| description |
Studying the spatial mutational and gene expression alterations in breast cancer could impact our understanding of breast cancer development. Here, the authors analyse a unique dataset of epithelial samples that highlight potential field cancerisation surrounding the primary tumour. |
| url |
https://doi.org/10.1038/s41467-017-01357-y |
| work_keys_str_mv |
AT moustafaabdalla mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT danhtranthanh mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT juanmoreno mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT vladimiriakovlev mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT ranjunair mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT nishakanwar mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT mohamedabdalla mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT jenniferpylee mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT jenniferyinyeekwan mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT thomasrcawthorn mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT keishawarren mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT nonaarneson mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT dongyuwang mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT nataliesfox mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT brucejyoungson mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT naomiamiller mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT alexandrameasson mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT davidmccready mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT weylleong mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT paulcboutros mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma AT susanjdone mappinggenomicandtranscriptomicalterationsspatiallyinepithelialcellsadjacenttohumanbreastcarcinoma |
| _version_ |
1721452177485987840 |