Toll-like receptor 4 enhancement of non-NMDA synaptic currents increases dentate excitability after brain injury

Toll-like receptor 4 enhancement of non-NMDA synaptic currents increases dentate excitability after brain injury

Concussive brain injury results in neuronal degeneration, microglial activation and enhanced excitability in the hippocampal dentate gyrus, increasing the risk for epilepsy and memory dysfunction. Endogenous molecules released during injury can activate innate immune responses including toll-like re...

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Bibliographic Details
Main Authors: Ying Li, Akshata A. Korgaonkar, Bogumila Swietek, Jianfeng Wang, Fatima S. Elgammal, Stella Elkabes, Vijayalakshmi Santhakumar
Format: Article
Language:English
Published: Elsevier 2015-02-01
Series:Neurobiology of Disease
Subjects:
Traumatic brain injury
Dentate gyrus
Hippocampus
Electrophysiology
Innate immune response
Excitability
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996114003672

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http://www.sciencedirect.com/science/article/pii/S0969996114003672

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