Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias

Light-induced depigmentation in planarians models the pathophysiology of acute porphyrias

Porphyrias are disorders of heme metabolism frequently characterized by extreme photosensitivity. This symptom results from accumulation of porphyrins, tetrapyrrole intermediates in heme biosynthesis that generate reactive oxygen species when exposed to light, in the skin of affected individuals. He...

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Bibliographic Details
Main Authors: Bradford M Stubenhaus, John P Dustin, Emily R Neverett, Megan S Beaudry, Leanna E Nadeau, Ethan Burk-McCoy, Xinwen He, Bret J Pearson, Jason Pellettieri
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-05-01
Series:eLife
Subjects:
planarian
porphyria
porphyrin
heme
ommochrome
pigment
Online Access:https://elifesciences.org/articles/14175

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