Medication Rule of Traditional Chinese Medicine on Primary Hepatocellular Carcinoma with Ascites

• Main Authors: ZHANG Fan, CHEN Bin, WU Yu'nan, PENG Jianping, JING Jing, SUN Kewei
• Format: Article
• Language: zho
• Published: Magazine House of Cancer Research on Prevention and Treatment 2019-10-01
• Series: Zhongliu Fangzhi Yanjiu
• Subjects: hepatocellular carcinoma with ascites; traditional chinese medicine; dialectical law; medication rule
• Online Access: http://html.rhhz.net/ZLFZYJ/html/8578.2019.19.0271.htm

Object To explore the clinical medication rule and feature of TCM on hepatocellular carcinoma with ascites. Methods We collected the clinical data of 186 hepatocellular carcinoma patients with ascites, established the clinical drugs database, and used frequency analysis and association rules to research the medication characteristics. Results In 186 patients, the proportion of TCM syndrome type from high to low in turn was liver blood stasis syndrome, liver blood stasis syndrome and spleen deficiency and dampness, spleen deficiency and dampness, liver depression and qi stasis and liver blood stasis syndrome, qi yin deficiency syndrome and dampness toxicity incandescence syndrome. Liver blood stasis syndrome had been considered with the highest treatment efficacy. The top 15 agent medicines were salvia miltiorrhiza, tulip, peach seed, pangolin, safflower, codonopsis pilosula, astragalus membranaceus, licorice, coix seed, poria cocos, hedyotis diffusa, scutellaria barbata, bupleurum, angelica sinensis and turtle shell. Conclusion The most common clinical syndrome type of hepatocellular carcinoma patients with ascites is liver blood stasis syndrome. "Promoting blood circulation and removing blood stasis, diuresis and dampness, invigorating spleen and regulating qi, clearing heat and nourishing yin" are the main principles of traditional Chinese medicine for hepatocellular carcinoma patients with ascites. Activating blood circulation and removing blood stasis are the important component of the treatment.