Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease

Cancer Imprints an Increased PARP-1 and p53-Dependent Resistance to Oxidative Stress on Lymphocytes of Patients That Later Develop Alzheimer's Disease

We have proposed that a common biological mechanism deregulated in opposite directions might explain the inverse epidemiological association observed between Alzheimer's disease (AD) and cancer. Accordingly, we showed that lymphocytes from AD patients have an increased susceptibility, whereas t...

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Bibliographic Details
Main Authors: Felipe Salech, Daniela P. Ponce, Carol D. SanMartín, Nicole K. Rogers, Mauricio Henríquez, Maria I. Behrens
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Neuroscience
Subjects:
cancer
AD
oxidative death resistance
lymphocytes
PARP-1
p53
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00058/full

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