Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays

Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays

The ability to form teratomas in vivo containing multiple somatic cell types is regarded as functional evidence of pluripotency for human pluripotent stem cells (hPSCs). Since the Teratoma assay is animal dependent, laborious, and only qualitative, the PluriTest and the hPSC ScoreCard assay have bee...

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Bibliographic Details
Main Authors:	Marga J. Bouma, Maarten van Iterson, Bart Janssen, Christine L. Mummery, Daniela C.F. Salvatori, Christian Freund
Format:	Article
Language:	English
Published:	Elsevier 2017-05-01
Series:	Stem Cell Reports
Subjects:	human pluripotent stem cell pluripotency assay teratoma PluriTest hPSC ScoreCard TeratoScore tumorigenicity malignancy differentiation-defective
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213671117301157

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