Jak Inhibitors Modulate Production of Replication Competent Zika Virus in Human Hofbauer, Trophoblasts, and Neuroblastoma cells

Jak Inhibitors Modulate Production of Replication Competent Zika Virus in Human Hofbauer, Trophoblasts, and Neuroblastoma cells

Zika Virus (ZIKV) is a Flavivirus that has been implicated in brain deformations, birth defects, and microcephaly of unborn fetuses and associated with Guillain-Barre syndrome.  Mechanisms responsible for transmission of ZIKV across the placenta to the fetus are incompletely understood.  Herein, we...

Full description

Bibliographic Details
Main Authors: Christina Gavegnano, Leda C. Bassit, Bryan D. Cox, Hui-Mien Hsiao, Erica L. Johnson, Mehul Suthar, Rana Chakraborty, Raymond F. Schinazi
Format: Article
Language:English
Published: Case Western Reserve University 2017-05-01
Series:Pathogens and Immunity
Subjects:
Zika, mother-to-child-transmission (MTCT), placenta, Hofbauer, trophoblasts, HIV, interferon, Jak-STAT, activation, ruxolitinib, CNS
Online Access:https://paijournal.com/index.php/paijournal/article/view/190

Similar Items

Similar Items