Non-Coding RNAs in Retinoic Acid as Differentiation and Disease Drivers

• Main Authors: Carlos García-Padilla, Estefanía Lozano-Velasco, Carmen López-Sánchez, Virginio Garcia-Martínez, Amelia Aranega, Diego Franco
• Format: Article
• Language: English
• Published: MDPI AG 2021-02-01
• Series: Non-Coding RNA
• Subjects: retinoic acid; microRNAs; lncRNAs; development; disease
• Online Access: https://www.mdpi.com/2311-553X/7/1/13

<b>: </b>All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. Thus, RA signalling deregulation has a major impact, both in development and disease, related in many cases to oncogenic processes. In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease.