TBC1d24-ephrinB2 interaction regulates contact inhibition of locomotion in neural crest cell migration
Group migration of cranial neural crest cells depends upon Eph-ephrin signalling. Here, the authors show that TBC1d24 complexes with ephrinB2 via Dishevelled to induce contact inhibition of locomotion by reducing membrane E-cadherin. Eph receptor binding dissolves this complex and disrupts migration...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05924-9 |
| Summary: | Group migration of cranial neural crest cells depends upon Eph-ephrin signalling. Here, the authors show that TBC1d24 complexes with ephrinB2 via Dishevelled to induce contact inhibition of locomotion by reducing membrane E-cadherin. Eph receptor binding dissolves this complex and disrupts migration. |
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| ISSN: | 2041-1723 |