The multicomponent approach to N-methyl peptides: total synthesis of antibacterial (–)-viridic acid and analogues

Two syntheses of natural viridic acid, an unusual triply N-methylated peptide with two anthranilate units, are presented. The first one is based on peptide-coupling strategies and affords the optically active natural product in 20% overall yield over six steps. A more economical approach with only f...

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Bibliographic Details
Main Authors: Ricardo A. W. Neves Filho, Sebastian Stark, Bernhard Westermann, Ludger A. Wessjohann
Format: Article
Language:English
Published: Beilstein-Institut 2012-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
Online Access:https://doi.org/10.3762/bjoc.8.234